CD274 and neoplasm: The results taken together suggest a possible scenario for biologic response processes to neoadjuvant anti-HER2 therapy in a population with HER2-positive/HR-positive disease: one cycle of neoadjuvant anti-HER2-therapy (± ET) can induce an early immune response, marked here by tissue levels of CD8 and PD-L1, and potentially marked by tumor-infiltrating lymphocytes (TILs).