A number of TF are known oncogenes, e.g., ELF3, ERBB2, ERBB3, GATA3, SOX2, SOX9, FOXA1, CCND1, while others act as tumor suppressors, e.g., ATM, ARID1A, CBL, CDKN2A, TBX3, and EGR1 [50]. This evidence concerns the gene ERBB3 and neoplasm.