Figure 1a shows an expression profile where the higher the lymphangiogenesis markers’ expression in the melanoma lymph nodes, the higher the expression of CD147. Immunohistochemical analysis also showed that the level of CD147 staining had the same trend as the intensity of the immunofluorescence of the lymphatic vessel markers LYVE-1 and Podoplanin. Moreover, intratumoral VEGFR-3 staining was more intense in melanoma lymph nodes containing high amounts of CD147 (Figure 1b,c). This evidence concerns the gene FLT4 and melanoma.