To our knowledge, there are no FDA-approved anti-lymphangiogenic drugs, although a recent Phase I dose-escalation study evaluating a human monoclonal antibody LY3022856/IMC-3C5, specifically targeting VEGFR-3 in solid tumors or in advanced colorectal cancers, was investigated but showed insignificant antitumor activity because of a limited observed efficacy on tumor growth with a median PFS of only 6.3 weeks [63]. Here, FLT4 is linked to neoplasm.