In contrast, COL11A1 knockdown (measured by Western blot and RT-PCR (Figure 1E and Figure S1I)) in A2780CIS cells (a cisplatin-resistant ovarian cancer cell line that expresses high levels of endogenous COL11A1 [9]) led to decreased phosphorylated and total HSP27 protein expression (Figure 1E) as well as HSPB1 (a gene encoding HSP27) expression (Figure 1F) compared to the scrambled control cells (as expected). The gene discussed is HSPB1; the disease is ovarian cancer.