To do this, we performed a protein kinase array on ES2 cells (an ovarian cancer cell line that expresses low levels of endogenous COL11A1 [8,9]) cultured on COL11A1 extract coated plates and discovered that COL11A1 induced expression of phosphorylated HSP27 at its serine 78 and 82 residues (S78/82) (Figure 1A,B). Here, COL11A1 is linked to ovarian cancer.