For example, a number of cancer antigens derived from members of the melanoma antigen gene protein family (MAGE), whose expression is restricted to reproductive tissues but which are also aberrantly expressed in a wide variety of cancer types, such as MAGA3(114–122), MAGEC(42–50), and MAGEA2(338–344), are produced by immunoproteasome but not by the constitutive proteasome [103,174]. The gene discussed is MAGEA2; the disease is cancer.