TP53 and cancer: p53 induces a remarkable variety of biological responses, ranging from transient or permanent growth arrest (senescence), induction of pro-oxidant response and apoptotic cell death [8], modulation of immune response [9], inhibition of metastatic potential/plasticity of cancer cells [10] or block of angiogenesis [11], regulation of autophagy [12] or iron-dependent form of cell death (ferroptosis) [13], to stimulation of DNA repair [14] and anti-oxidant responses [15], as well as control of metabolism [16] and repression of pluripotency [17].