Although both genes have not been extensively studied in melanoma so far, MAP3K2 participates in regulation of several pathways such as MAPK signaling, β-catenin pathway and Hedgehog (Hh) pathway in medulloblastoma and osteoblasts [173,174], and FJX1 promotes angiogenesis in colorectal carcinoma [175]. This evidence concerns the gene FJX1 and melanoma.