Another lncRNA ANRIL (antisense non-coding RNA in the INK4A locus) has been originally identified in familial melanoma patients with a large germline deletion in the INK4B-ARF-INK4A gene cluster [66] and has been found to be dysregulated in several other cancers, such as gastric or breast cancers [67,68]. The gene discussed is CDKN2A; the disease is cancer.