Although CDR1as has been primarily thought to negatively regulate miR-7 acting as miRNA sponge in neuronal cells [86,87], Hanniford et al. [44] failed to detect changes in miR-7 activity after CDR1as depletion and inhibition of miR-7 did not revert the effects of CDR1as depletion on melanoma cell invasion, providing evidence that miR-7 deregulation is not a critical mediator of CDR1as silencing effects in melanoma. This evidence concerns the gene LINC00632 and melanoma.