miR-33a is a well-known tumor suppressor downregulated in melanoma that targets snail family zinc finger 2 (SNAI2) and hypoxia inducible factor 1 (HIF-1) transcription factors positively regulating EMT and glycolysis, respectively [129,161], and tumor-promoting cyclin dependent kinase 16 (CDK16) [162]. The gene discussed is HIF1A; the disease is neoplasm.