The lncRNA X-inactive specific transcript (XIST) is overexpressed in melanoma and regulates the following miRNA-mRNA axes: miR-23a-3p/GINS complex subunit 2 (GINS2) [149] and 139-5p/Rho associated coiled-coil containing protein kinase 1 (ROCK1) [150]. Here, ROCK1 is linked to melanoma.