miR-31 host gene (MIR31HG) lncRNA is upregulated in OIS upon BRAF overexpression, binds directly to SUZ12 polycomb repressive complex 2 subunit and EZH2, thus is required for the repression of the INK4A locus, whereas knockdown of MIR31HG promotes a p16INK4A-dependent senescence of melanoma cells [50]. The gene discussed is MIR31HG; the disease is melanoma.