PIK3CA and neoplasm: Knockdown of H19 inhibits phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PI3K)/AKT serine/threonine kinase 1 and nuclear factor kappa B subunit 1 (NF-κB) signaling, reverses EMT-like process in melanoma cell lines and suppresses tumor growth in immunocompromised mice with melanoma [164,165].