In a previous study, median serum GDF-15 levels were higher in cancer patients with anorexia (1224.1 pg/mL) than in patients without anorexia (812.4 pg/mL) [34], where the cut-off value for anorexia was set at the lowest Functional Assessment of Anorexia/Cachexia Treatment (FAACT) score tertile, similar to the consensus definition of anorexia (FAACT ≤ 24) [38]. This evidence concerns the gene GDF15 and cancer.