Of note, the combination of the 27-gene IO signature and PD-L1 expression by IHC had greater predictive power than either alone, and the OR was maximized when the 27-gene IO signature was combined with high PD-L1 positivity, defined as PD-L1 expression in more than 50% of tumor cells and/or more than 10% of immune cells. Here, CD274 is linked to neoplasm.