CD274 and neoplasm: For patients with either a high level of PD-L1 positivity (expression in >50% of tumor cells and/or >10% of immune cells) or TNBC positive for the 27-gene IO signature, the PPV, NPV, PLR, and NLR were 0.68, 0.72, 2.53, and 0.47, respectively, and the OR was higher than for any other subtyping method or combination (OR, 6.53; 95% CI, 1.90–22.50; p = 0.003).