TP53 and head and neck squamous cell carcinoma: On the contrary, we have found that HPV-positive SCCHN cells display greater metabolic diversity than cells in which p53 function is compromised (either through genetic mutation or experimentally by RNAi), indeed comparable to that observed in p53 wild-type cells [15], and by extension require a combinatorial anti-metabolic approach targeting both mitochondrial respiration and glycolysis to be sensitised to the effects of IR.