Second, when we analyzed resistant vs. cisplatin-sensitive cell lines, the potential cisplatin transport channel candidates CTR1, OCT1, or MRP1 were neither up- nor downregulated (Figure 2f) in contrast to the downregulation of VRAC further underlining VRAC’s relevance for drug resistance in HNSCC. The gene discussed is SLC31A1; the disease is head and neck squamous cell carcinoma.