Second, when we analyzed resistant vs. cisplatin-sensitive cell lines, the potential cisplatin transport channel candidates CTR1, OCT1, or MRP1 were neither up- nor downregulated (Figure 2f) in contrast to the downregulation of VRAC further underlining VRAC’s relevance for drug resistance in HNSCC. This evidence concerns the gene ABCC1 and head and neck squamous cell carcinoma.