To probe an association between TDS and DNAm age drift, we calculated TDS in each tumor using the expression panel of 12 selected genes (TG, TPO, SLC26A4, SLC5A5, SLC5A8, DIO1, DIO2, DUOX1, DUOX2, KIT, TFF3 and FHL1), as described [25], and significantly lower TDS values were observed in tumors with HDDA (Figure 5A,B, p = 0.015). Here, DIO2 is linked to neoplasm.