AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive: Upon treatment with TKIs the PI3K/AKT signaling is blunted in CML (including LSCs) leading to inhibition of the pro-survival β-catenin signaling [142]; yet it also enables activation of FOXOs, likely offering to LSCs a BCR-ABL1-independent route for survival.