KMT2A and acute myeloid leukemia: The exact mechanism behind the upregulation of CSPG4 expression in AML with KMT2A-r is yet to be determined; nevertheless, some of the aberrations in epigenetic regulators that were found in CSPG4-expressing blasts without KMT2A-r are described to show similar HOXA gene expression profiles to KMT2A-r [31,32].