TGFB1 and neoplasm: There is a complicated interaction between CSC and CSC niches; it was summarized that CAF could regulate the proliferation, expansion and self-renewal via secreting some cytokines, such as CCL2, IGF-1, TGF-β and HMGB-1; what’s more, researchers found that CAF could induce tumor cells dedifferentiated change via secreting HGF.