EMT also shares many of the same signal pathways, such as TGF-β and Hh with CSCs and it was proposed that EMT may be the reason for the acquisition or maintenance of the stemness of CSCs; it was found that the stemness of CSCs and EMT could be regulated by some signal pathway inhibitors, and targeting the EMT phenotype could potentially inhibit tumor cells, even CSCs. This evidence concerns the gene TGFB1 and neoplasm.