STAT3 and neoplasm: The abnormal activation of the JAK/STAT signal pathway promotes tumorigenesis, and many JAK/STAT signal pathway inhibitors, such as JAK inhibitors (INCB018424 and AZD1480), STAT inhibitors (STAT3 inhibitor and STAT5 inhibitor) and phytochemicals(phenolics, polyphenols, terpenoids, alkaloids, saponins, steroids, lignin and phytoalexin) were found to inhibit tumor growth [125].