It was indicated that MDSC could increase CSC stemness and tumor cell PD-L1 expression by the production of PGE2 in epithelial ovarian cancer, and also MDSC might be an effective target to inhibit ovarian tumor cells via reducing ovarian CSC stemness and PD-L1expression [191]; meanwhile, Xiaofeng Li et al. revealed that MDSC could also promote CSC stemness in ovarian cancer via inducing the CSF2/p-STAT3 signaling pathway, and they thought it could enhance the efficacy of conventional treatments by targeting MDSC and colony-stimulating factor 2 (CSF2) [192]. This evidence concerns the gene STAT3 and neoplasm.