CD274 and neoplasm: According to the clinical guidelines of the National Comprehensive Cancer Network (NCCN) version 2.2021, non-invasive N2 cT1-2, T3 tumours can be treated with induction chemotherapy (ChT) with subsequent surgical rescue or concomitant chemo-radiotherapy (CRT) with response-dependent radical intent, or immediately with radical concomitant CRT followed by consolidation durvalumab according to the indications in each country (only approved in PD-L1 ≥ 1% by the European Medicines Agency).