Vazquez Rodriguez et al. showed the estrogen-mediated lysine-dependent upregulation of the 35 kDa subunit of the U2AF splicing factor (U2AF1) and ribophorin-2 (RPN2) increased the neutrophil-mediated dissemination ability of the ER+ breast cancer cells via increased cell proliferation, migration and expression of cell adhesion genes [136]. The gene discussed is RPN2; the disease is breast cancer.