MSH2 and hereditary nonpolyposis colon cancer: It was first described in 2006 by Chan et al. [147], where a three-generation Chinese family with hereditary nonpolyposis colorectal cancer (HNPCC) exhibited germline allele-specific hypermethylation in the MSH2 promoter region without having mutations in DNA mismatch repair genes (MMR); this was key to explain the etiology of Lynch syndrome in the family.