Although several prior publications provide an excellent overview of the effect of SFN in cancer [50,51,52,53,54,55,56,57,58,59], these reports represent narrative reviews that focused mainly on SFN’s source, biosynthesis, and mechanisms of action in modulating specific pathways involved in cancer without a comprehensive review of SFN’s role or value for prevention of various human malignancies. Here, SFN is linked to cancer.