TNF and cancer: Results showed that while HT-29 and RKO cancer cells stimulated both pro- and anti-inflammatory cytokine production by PBMCs, the addition of SFN exerted a concentration-dependent inhibitory effect on inflammatory cytokine production by these cells, specifically with tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, IL-2, IL-10, and interferon γc (IFNγc).