NFE2L2 and malignant colon neoplasm: Another transcriptomic study conducted by Johnson et al. [142], using SFN-treated human colon cancer cell lines, HT-29 and HCT-116, demonstrated that SFN strongly induced the expression of NQO1, several other Nrf2-dependent targets, and Loc344887 (NMRAL2P), a noncoding RNA that acts as a novel, functional pseudogene for the NmrA-like redox sensor and coregulator of NQO1.