By treating wild type (WT) and Nrf2-deficient (Nrft2−/+) mice with the colon carcinogen dimethylhydrazine (DMH) and subsequent dietary SFN (400 ppm) treatment, researchers demonstrated that WT mice were more susceptible to colon tumor induction than Nrf2−/+ mice. This evidence concerns the gene NFE2L2 and colonic neoplasm.