HMOX1 and breast cancer: Lo and Matthews [117] exposed MCF-7 breast cancer cells to SFN and observed an increase in nuclear factor erythroid-2-related factor 2 (Nrf2), NADPH-dependent oxidoreductase 1 (NQO1), and heme oxygenase 1 (HMOX1) mRNA, indicating that SFN plays an important role in protecting cells from oxidative stress by upregulating phase II detoxifying enzymes.