CASP3 and melanoma: Hamsa et al. [216] treated B16F-10 melanoma cell lines with SFN and witnessed a reduction in cell viability and increased apoptosis via induction of caspase-3, caspase-8, caspase-9, and Bax, as well as decreased expression in Bcl-2, IL-1β, IL-6, TNF-α, IL-12p40 C-Fos, ATF-2, CREB, and NF-κB.