DIABLO and glioblastoma: Karmakar et al. [208] performed a study treating glioblastoma cell lines T98G and U87MG with SFN and reported a decrease in cell viability and increase in apoptosis via upregulation of caplain, proapoptogenic mitochondrial protein Smac/Diablo, apoptosis inducible factor (AIF), as well as increased expression of caspase-3, caspase-9, caspase-12, Bax:Bcl-2, cyt.