Figure 6E depicts that overexpression of miR-33b led to much less metastatic tumor seeding in distant organs of mice. Subsequently, IHC was performed to assess the effect of miR-33b on the TAK1/FASN/CPT1A/NF-κB axis and Ki67 expression in vivo. The results showed that miR-33b overexpression reduced TAK1, FASN, CPT1A, P-IKKα/β, P-IκBα, and Ki67 protein expression in xenograft tumor tissues (Figure 6F). The gene discussed is MKI67; the disease is neoplasm.