MARK2 and neoplasm: Since the unique differences in CRL-1424 melanoma cells reside in the presence of a STK11 mutation, a gene encoding for serine/threonine kinase family that acts not only as a tumor suppressor, but is also involved in metabolic regulation, it is possible that the effects of OSA-derived plasma exosomes on the CRL-1424 melanoma cells may specifically involve STK11-regulated pathways.