Last, when screening for MYCN co-dependencies that were differentially expressed between mice of both 2 and 6 weeks of age compared to week 1 (Figure 4A), four overlapping genes could be retrieved, with high expression of three of those significantly correlating to poor overall patient survival in human primary neuroblastoma (Figure 5D, top, GSE45547, n = 649). Here, MYCN is linked to neuroblastoma.