In conclusion, we present an in-depth characterization of the dynamic transcriptome profiles of TH-MYCN-driven murine hyperplastic lesions and established tumors and the integration with both primary human neuroblastoma tumor expression data, epigenetic and functional genomics data to identify and validate candidate cooperating dependencies, suitable as putative candidates for a precision medicine approach in neuroblastoma. This evidence concerns the gene MYCN and neuroblastoma.