TPRKB and neoplasm: From the four other core KEOPS protein complex encoding components (c14orf142, TP53RK, TPRKB and OSGEP), Osgep is also significant differentially expressed during murine TH-MYCN tumor development compared to wild type (Figure S2A), while high expression of all components, except OSGEP, was significantly correlated to poor overall patient survival (GSE45547, n = 649) (Figure S2B).