ASCL1, together with PHOX2B, is a known critical developmental factor in sympathetic and parasympathetic nervous system development and has been reported as a canonical factor of the adrenergic core regulatory circuitry in neuroblastoma co-regulated by MYCN and LMO1 [44], but its specific oncogenic dependency role in this adrenergic circuitry is elusive. Here, MYCN is linked to neuroblastoma.