CLSPN and neuroblastoma: Single-cell RNA-seq data of the sympathoadrenal lineage and adrenal medulla respectively indicate that CLSPN displays nearly exclusive strong expression in the proliferating sympathoblasts [49] and cycling neuroblast population [50] (Figure 5D, bottom) We also evaluated the overlap of the set of significantly upregulated genes in the course of murine TH-MYCN-driven neuroblastoma tumor development with the neuroblastoma specific dependencies as defined by the recent pediatric cancer dependency map from Dharia et al. [68].