ALK and neuroblastoma: In addition, other putative interesting candidates include amongst others CBX2 (a core PRC1 subunit required for binding to H3K27me3 marked domains), CDCA8 (a subunit of the “Chromosomal Passenger complex” (CPC) and direct MYCN target gene contributing to the aggressive phenotype of MYCN-amplified neuroblastoma [77]), Claspin (a key mediator of the ATR-CHK1 pathway), and PIM1 (a key driver of ALK inhibitor resistance in neuroblastoma [78]).