Interestingly, both MEIS2 and ASCL1 revealed a pattern of dynamic regulation during murine TH-MYCN-driven neuroblastoma tumor formation that clearly deviated from those observed for other canonical CRC members (HAND2, PHOX2B, GATA3 and ISL1), pointing towards a putative distinct role for MEIS2 and ASCL1 in the core regulatory circuit network during tumor formation. This evidence concerns the gene ISL1 and neuroblastoma.