ESR1 and neoplasm: The absence of androgen receptor correlates positively with mean tumor size (in ER+ tumors), Nottingham grade and the presence of necrosis [165], AR-positivity can be associated with older age of onset, lower stage and grade of cancer, 27% reduction of overall breast cancer mortality, 46% reduction of mortality for ER+ breast cancers and 62% increase of mortality for ER- breast cancers, although only for the 7 years postdiagnosis, as a 48% increase in mortality in AR+ cancers was noted thereafter.