AKT1 and alcohol dependence: In 2016, Kim and colleagues reported that treatment with disulfiram (DSF) (Table 1), an anti-alcoholism drug with antitumor activity [72], in the presence of copper (Cu)-induced apoptosis, was associated with a marked decrease in HER2 and truncated p95HER2, phospho-HER2 (p-HER2), HER3, phospho-HER3 (p-HER3) and phospho-Akt (p-Akt), which was simultaneously accompanied by decreased ALDH1 activity and decreased MFE.