GLI1, as in other tumors, was found to promote iCCA survival, growth, and EMT reprogramming [113,139], together with GLI3, which directly binds to the promoter of death receptor 4 (DR4), repressing its transcription and thus preventing TRAIL-dependent cholangiocarcinoma cell death [140]. This evidence concerns the gene TNFRSF10A and cholangiocarcinoma.