High PPP2CA expression in tumors leads to shorter overall survival in both esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) patients (p = 0.065 and 0.0085, respectively, log-rank test), suggesting the important role of PP2A in ESCC progression. This evidence concerns the gene PPP2CA and esophageal squamous cell carcinoma.