Specifically, LB-100 treatment (1) promoted faster degradation of MCL1 and accordingly decreased OCR in resistant cells (Figure 4B–D); (2) induced more apoptosis in nab-PTX resistant cells (Figure 4B,C, Figure 5A–E); and (3) efficiently inhibited the tumor growth in nab-PTX resistant xenografts (DR150) but not in nab-PTX sensitive xenografts (KYSE150) (Figure 5F,G). Here, MCL1 is linked to neoplasm.