WFDC2 and neoplasm: There is growing evidence that HE4 may be useful as a prognostic marker in EC, with many studies showing an association between serum HE4 and poor prognostic histopathological factors, including ≥50% MI [27,31,35,42,55,59,60,61,62,63,64,65,66,67,68,69,70], CI and stage [42,60,65,66,69], presence of LVSI [31,42,55,60,64,66,68,69], tumour size [31,55,67,68,69,70] and LNM [27,31,32,44,55,60,64,65,68,69].