To identify relevant studies, the Medline, Embase and Cochrane library were systematically searched from database inception to July 2021 for English language articles using the following keywords: “endometrial cancer”, “endometrial carcinoma”, “endometrial hyperplasia”, “atypical endometrial hyperplasia” associated with “HE4”, “human epididymis protein 4”, “WFDC2”, “WAP Four-Disulfide Core Domain 2”. The gene discussed is WFDC2; the disease is endometrial carcinoma.