HDAC1 and cancer: HDAC-1 and -2 cytoplasmic staining has been reported in various normal tissues, such as in pancreatic and hepatic parenchyma, small bowel, and gastric mucosa, and in non-tumoral ocular structures [17,21], as well as in malignant neoplasms, such as salivary gland tumors, alveolar soft part sarcoma, and neuroblastoma [18,21,29].