The fact that the presence of nuclear HDAC-2 expression remains in combination with lower tumor size, absence of metastatic disease, and spindle cell morphology, an independent factor of better prognosis in multivariate survival analysis, implicates a possible unknown intrinsic role of HDAC-2 in a patients’ prognosis, which cannot be attributed to its association with these parameters. The gene discussed is HDAC2; the disease is metastatic neoplasm.