According to hierarchical clustering of basal and luminal biomarkers using whole-transcriptome expression data from independent cohorts of 937 bladder cancer samples, two signature markers, one luminal (GATA3) and the other basal (KRT5/6), were sufficient to classify bladder cancer into the categories of basal and luminal with 90% accuracy [30]. The gene discussed is KRT5; the disease is urinary bladder cancer.