Another study showed that identification of a T-cell-inflamed tumor microenvironment was possible with the presence of concordance with CD8+ T cell infiltration, and that T-cell-inflamed tumors were associated with upregulation of genes encoding immune checkpoint proteins PD-L1, FOXP3, IDO, TIM3, and LAG3, suggesting potential sensitivity to immune checkpoint blockade [47]. The gene discussed is CD274; the disease is neoplasm.