The overexpression of HMGB1, a key target of miR-142-3p in breast cancer cells, restored doxorubicin resistance by promoting apoptosis and inhibiting autophagy via miR-142-3p upregulation, suggesting that the miR-142-3p/HMBG1 axis is a novel target to overcome drug resistance in patients with breast cancer [78]. The gene discussed is HMGB1; the disease is breast carcinoma.