Prophylactic vaccination against ICRP-induced cell death prevented tumorigenesis in BALB/c mice; induced long-term antitumor memory with DC maturation in lymph nodes; increased the numbers of CD8+ T cells in the lymph nodes, peripheral blood, and tumor sites; and showed ex vivo tumor-specific cytotoxicity by splenocytes [129]. Here, CD8A is linked to neoplasm.