This includes MCC950, a diarylsulfonylurea-containing compound that inhibits ATP hydrolysis in the NACHT domain of NLRP3, which has been found to suppress MDSCs and regulatory T cells while enhancing the numbers of effector T cells in murine models of head and neck squamous cell carcinoma [42,76]. This evidence concerns the gene NLRP3 and head and neck squamous cell carcinoma.