Prior work has supported a role for NLRP3 in tumor immunosurveillance, including studies showing the NLRP3 inflammasome to upregulate PD-L1 expression and suppress the generation of T cell responses in diffuse large B cell lymphoma while also driving metastatic progression in the B16/F10 melanoma model by inhibiting NK cell activity [40,41]. This evidence concerns the gene CD274 and melanoma.