NLRP3 and breast carcinoma: Further studies have also demonstrated a pro-tumorigenic role for NLRP3 under the regulation of interleukin-1 receptor-associated kinase-1-mediated JNK1/2 phosphorylation in hepatocellular carcinoma cell lines as well as the control by estrogen receptor signaling in endometrial carcinoma cell lines and breast carcinoma cell lines [33,34,35].