NLRP3 and neoplasm: After briefly discussing prior studies implicating a role for the NLRP3 inflammasome in both cancer progression and the regulation of the adaptive immune system, this review then focuses on developments that indicate an important role for the tumor-intrinsic NLRP3 inflammasome in acquired immunotherapy resistance via the induction of heat shock protein-70 (HSP70) release and the ultimate recruitment of granulocytic myeloid-derived suppressor cells (PMN-MDSCs).