NLRP3 and familial pancreatic carcinoma: These data are also consistent with studies performed in a transgenic p48Cre;LSL-KrasG12D model and an orthotopic Pdx1Cre;LSL-KrasG12D;Tp53R172H model of pancreatic cancer, which demonstrated NLRP3 signaling in macrophages to drive M2 polarization and suppress both the activation and infiltration of CD4+ and CD8+ T cells in pancreatic tumors [43].