This is exemplified by cancer-associated fibroblast (CAF) expression of NLRP3, which contributes to tumorigenesis and metastasis in several breast cancer models, including the syngeneic PyMT-derived mammary tumor cell lines, AT3 and Met-1, and the 4T1 mammary carcinoma cell line [28]. This evidence concerns the gene NLRP3 and breast cancer.