CD4 and malignant colon neoplasm: While there have been few studies linking the inhibition of HSP70 with anti-tumor immunity, a recent study performed in the MC38 and CT26 murine colon cancer cell lines as well as the HT-29 human colon cancer cell line demonstrated the HSP70 inhibitor, AP-4-139B, to induce an immunogenic form of cell death that promotes the recruitment of both CD4+ and CD8+ T cells [86].