NLRP3 and familial pancreatic carcinoma: Better known for its anti-allergy properties, tranilast (N-3,4-dimethoxycinnamoyl-anthranilic acid), which also binds to the NACHT domain to prevent NLRP3 oligomerization, has been shown to suppress the progression of a variety of cancer types in pre-clinical studies, including gastric cancer, pancreatic cancer, glioma, and osteosarcoma [79].