HIF-1α production induced by hypoxic conditions was shown to cooperate with CAFs to increase the expression of TGF-β2, which non-canonically activated the transcription of GLI2 in cancer stem cells, thus leading to increase stemness, dedifferentiation, and resistance to FOLFOX (combination of 5-FU and oxaliplatin) chemotherapy. The gene discussed is GLI2; the disease is cancer.