Notably, a study by Yao et al. demonstrated a noncanonical regulation of GLI1 by p-AKT/mTOR signaling to promote cisplatin resistance in GC cell lines which can be reversed by the inhibition of GLI1 or p-AKT activity [129], and together with the previous data, suggests that cisplatin resistance can be regulated by noncanonical regulation of GLI function. Here, AKT1 is linked to gastric cancer.