LDHA and esophageal squamous cell carcinoma: Notably, the treatment of DHA suppresses the activation of the Hh pathway that led to a decrease in both cell proliferation and CSC traits, thus sensitizing ESCC to the cytotoxicity effect of cisplatin in both in vitro ALDH+ TE-1 cells and in vivo BALB/c nude mice bearing TE-1 xenograft models.