SHH and non-small cell lung carcinoma: An initial experiment by Ahmad et al. revealed that the transcriptional upregulation of Shh by TGF-β1 induced EMT phenotype in the non-small cell lung carcinoma (NSCLC) A549 cell line [142], and further study by the researchers showed that the inhibition of Hh signaling with GDC0449 or siRNA-mediated Shh knockdown sensitized these EMT cells to cisplatin.