Besides OC, Cui et al. reported that Shh overexpression or siRNA-mediated knockdown of Shh led to increased and decreased PTCH1 expression and cisplatin-induced cytotoxicity of esophageal squamous cell carcinoma (ESCC) KYSE510 cells, respectively [125]. The gene discussed is PTCH1; the disease is esophageal squamous cell carcinoma.