Conversely, the degradation of HIF-1α by oroxylin A or the inhibition of Hh/GLI1 signaling by cyclopamine led to the downregulation of the HIF-1α/Hh pathway and the increased expression of SUFU, thus restoring glioma cells’ chemosensitivity to TMZ [75]. This evidence concerns the gene GLI1 and central nervous system cancer.