GLI2 and hepatocellular carcinoma: In Huh-7 and HLE DN hepatoma subpopulations, higher Hh pathway (PTCH1, GLI1, GLI2) activity was associated with enhanced invasive capability, EMT acquisition (decrease E-cadherin and increase vimentin), and increased ABC transporter (ABCC1 and ABCB2) expression, resulting in enhanced chemoresistance [132,133,134].