SMO and neoplasm: Notably, KPC mice were not responsive to the treatment of gemcitabine alone; however, SMO inhibition with IPI-926 resulted in a marked increase in microvessel density (MVD) and improved perfusion that, in turn, correlated with more effective delivery of gemcitabine to KPC mice tumor tissues, as indicated by elevated intratumoral levels of gemcitabine metabolites dFdCTP.