GLI2 of the Hh signaling pathway was reported by Ding et al. to regulate the ABCC1 transporter in Huh-7 DN (CD133-/EpCAM-) and trans (CD133−/EpCAM− transwell-selected; EMT phenotype) hepatoma subpopulations to confer sorafenib drug resistance [132]. Here, PROM1 is linked to hepatocellular carcinoma.