Anyhow, the expression of both upstream and downstream Hh components, including Shh/Ihh, PTCH1, SMO, SUFU, and especially GLIs, has all been implicated in cancer chemoresistance one way or another, which suggests the availability of one or more potential therapeutic Hh targets for overcoming chemoresistance in Hh-promoting cancers. This evidence concerns the gene SUFU and cancer.