The presence of constitutional symptoms was significantly associated with higher plasma levels of MALAT1 (p = 0.0302) or GAS5 (p = 0.0306), whereas splenomegaly was correlated to higher LINC01268 (p = 0.0012), MALAT1 (p < 0.0001) or GAS5 levels (p = 0.0006) (Table 1). The gene discussed is GAS5; the disease is Splenomegaly.