The expression of TMEM48, TMEM206, and TMEM22 correlated with HNSCC risk factors such as alcohol consumption (p = 0.0324, p = 0.0209, p = 0.0109, respectively); the expression of ANO1, TMEM158, RTP3, and TMEM213 correlated with smoking (p = 0.0016, p = 0.0032, p = 0.0002, p = 0.0005, respectively). Here, TMEM158 is linked to head and neck squamous cell carcinoma.