For TMEM22, TMEM97, TMEM116, TMEM140, TMEM156, and TMEM213 the elevated expression levels were associated with higher (G3 + G4) cancer grade (p = 0.0012, p = 0.0002, p = 0.0014, p = 0.0348, p < 0.0001, p = 0.0208, respectively) in contrast to TMEM45B and TMEM158 which were highly expressed in G1 + G2 tumors (p < 0.0001 and p = 0.0367). The gene discussed is TMEM116; the disease is cancer.