TPO and thyroid gland disorder: Thyroid dyshormonogenesis is associated with multiple genetic defects, including dual oxidases (DUOXs; DUOX1 and DUOX2), and its maturation factors (DUOXA1 and DUOXA2), thyroid peroxidase (TPO), thyroglobulin (TG), dehalogenase 1 (DEHAL1) and solute carrier families: 26 (SLC26A4 or PDS) and 5 (SLC5A5 or NIS) [1,4].