GFAP and Huntington disease: We first examined the morphology of astrocytes using an immunohistochemical staining for GFAP and found that HD cases displayed a significant increase in GFAP+ expression (t(19) = 2.639, p = 0.016), alongside an increase in GFAP+ cell area (t(19) = 3.443, p < 0.024), indicative of astrogliosis (see Fig. 2a).