Importantly, HD cases displayed a significant reduction in D2-like receptor expression compared to controls both in terms of total expression (i.e., including all Dapi+ cells which expressed D2R) (t(18) = 4.631, p < 0.001, see Fig. 2d) and on GFAP+ astrocytes specifically (t(18) = 6.549, p < 0.001, Fig. 2e). This evidence concerns the gene GFAP and Huntington disease.