Hypoxia facilitated NSCLC cells to generate more neutrophil chemokines, and CXCL6 increased the most among all the increased chemokines (CXCL1, CXCL2, CXCL5, CXCL6, CXCL8, and CCL3) as detected by RT-PCR (Figure 4b). This evidence concerns the gene CXCL2 and non-small cell lung carcinoma.