Moreover, data validation based on GSE57691 and GSE7084 verified these four genes were all up-regulated in AAA samples compared to normal samples, however, further bioinformatics analysis based on GSE57691 and GSE98278 showed only POU2AF1 was consistent statistically significance in large AAA samples compared to small AAA samples. The gene discussed is POU2AF1; the disease is triple-A syndrome.