Numerous studies have also shed light on the correlation of B lymphocytes produced immunoglobulins such as IgG and IgE with AAA [48,49].Moreover, elevated immunoglobulins activate the complement cascade through the classical pathway, the lectin pathway and the alternative pathway, which was reported to contribute to the membrane attack complex and aggravate the aortic inflammatory responses [50–53]. This evidence concerns the gene IGHE and triple-A syndrome.