Hence, it is believed that a population that has been living in malaria-endemic areas will have a higher proportion of compensatory genetic variant (T-allele of ACE2 rs2106809) leading to a lower ACE2 level/activity (protective for SARS-CoV-2 infection) and higher AngII levels (protective for severe/cerebral malaria but augmentative for COVID-19-related pathologies) [44]. The gene discussed is ACE2; the disease is cerebral malaria.