When the COVID-19 case burden was superimposed on the available ACE2 rs2106809 T-allele data, it is evident that the case burden was in the lower range in African countries (Nigeria, Kenya, Gambia and Sierra Leone), supporting the hypothesis that the T-allele of ACE2 rs2106809 might protect against SARS-CoV-2 infection. The gene discussed is ACE2; the disease is COVID-19.