ACE2 and malaria: Based on the current understanding and availability of data, it can only be suggested at this point that the ACE2 genetic variant with rs2106809 T-allele might get selected in those populations that are/have been under malaria ‘pressure’, thus reducing the risk of SARS-CoV infection, and if infected due to any other comorbidities they may have more chance of developing severity owing to the ACE2 and angiotensin imbalance.