Attempts to link malaria and COVID-19 pathogenesis have thus far speculated a protective role of malaria exposure in either the reduced risk of infection and/or severity of SARS-CoV-2 disease based on non-specific immunomodulation due to commonly used anti-malaria drug, chloroquine [67], or reduced genetic susceptibility of the malaria-exposed population through yet unknown ACE2 polymorphisms [68]. This evidence concerns the gene ACE2 and infection.