Based on the current understanding and availability of data, it can only be suggested at this point that the ACE2 genetic variant with rs2106809 T-allele might get selected in those populations that are/have been under malaria ‘pressure’, thus reducing the risk of SARS-CoV infection, and if infected due to any other comorbidities they may have more chance of developing severity owing to the ACE2 and angiotensin imbalance. Here, ACE2 is linked to severe acute respiratory syndrome.