On a different note, it has already been strongly hypothesized that the T-allele of ACE2 rs2106809 (as opposed to its C-allele) decreases the ACE2 expression/activity and the ensuing increased AngII forms the basis for protection against severe malaria on one hand but predisposes to hypertension on the other [21,44–46]. This evidence concerns the gene ACE2 and malaria.