This contrasts with LeuRS variants identified in P. aeruginosa such as T323P, T327P, and V429M from Hernandez et al. or LeuRS variants such as T322I, D326N, A414V, and R435H identified in a phase 2 clinical trial for complicated urinary tract infections caused by E. coli from O’Dwyer et al. [28,30]. The gene discussed is LARS1; the disease is urinary tract infection.