We first utilized a haploidentical BM transplant (BMT) model (B6D2F1 [H-2b/d] B6C3F1 [H-2b/k]), in which lethally irradiated B6C3F1 mice were transplanted with splenocytes and T cell–depleted (TCD) BM cells from B6D2F1 mice and recipient-type (B6C3F1) MLL-AF9 AML. Here, KMT2A is linked to acute myeloid leukemia.