CSF3 and neoplasm: The mechanisms by which neutrophilia is induced in cancer patients are not fully understood, although aggressive tumors have been shown to secrete granulocyte colony-stimulating factor (G-CSF) at the onset of malignant transformation, resulting in tumor reprogramming of hematopoiesis in the bone marrow and the systemic expansion of circulating neutrophils, which preferentially accumulate in the lungs and facilitate metastatic seeding [22].