Immunohistochemistry shows that GPX4 is up-regulated in neurons of the SN and associated with dystrophic axons in the striatum of PD (Bellinger et al. 2011) suggesting, that GPX4 colocalizes with alpha-synuclein (α-syn) positive nigral LB and dystrophic TH-positive fibres in the putamen. Here, GPX4 is linked to Parkinson disease.