Consequently, disruption of mitochondria function may provoke disastrous events such as reduction of respiratory chain activity reported in PD (Schapira et al. 1989, 1990; Reichmann and Riederer 1989; Mizuno et al. 1989), production of more free radicals, profound effects on iron metabolism since mitochondria is involved in the production of haem and iron cluster proteins (Richardson et al. 2010), thereby suggesting that the nigral mitochondrial dysfunction may affect the iron metabolism via activity of ferrireductase/α-syn and subsequently resulting in the elevation of iron in PD. The gene discussed is STEAP3; the disease is Parkinson disease.