The MDVR cells express higher levels of several cancer drivers compared to parental LNCaP cells (Supplementary Fig. 2), including SOX9 (an important transcription factor and CRPC driver (Wang et al. 2008, Ma et al. 2016)), YAP1 (Kuser-Abali et al. 2015), HER3 (Soler et al. 2009), phospho-Akt, SRC-3 (an important transcriptional coactivator (Zhou et al. 2005, Geng et al. 2013, Foley & Mitsiades 2016)), and EZH2 (Varambally et al. 2002, Bryant et al. 2007, Yu et al. 2010, Xu et al. 2012). The gene discussed is AKT1; the disease is cancer.