In order to further validate these observations, we next compared our signatures of dilazep treatment of our three PC cell lines against several publicly available prostate-specific signatures of c-MYC activity: (1) following knockdown of c-MYC via siRNA in LNCaP, DU145, and PC3 PC cells (Koh et al. 2011), (2) upon overexpression of c-MYC for 5 or 12 h in LNCaP cells (GSE51384 and Barfeld et al. 2015), and (3) upon c-MYC overexpression in epithelial cells isolated from the mouse ventral prostate (GSE37428 and Ju et al. 2013). The gene discussed is MYC; the disease is pachyonychia congenita.