Collectively, our findings suggests that c-MYC expression and function are highly GATA2-dependent in PC cells, and extremely sensitive to GATA2 inhibition, thus providing an opportunity to effectively silence the expression of an otherwise undruggable major driver of PC (Buttyan et al. 1987, Bernard et al. 2003, Edwards et al. 2003, Ellwood-Yen et al. 2003). This evidence concerns the gene MYC and pachyonychia congenita.