Interestingly, they did not find any mutation in the remained 28 families, which means pathogenic genomic alterations in the MASP1, COLEC11, and COLEC10 genes are responsible for the minority of affected individuals with 3MC syndrome phenotypes, and the other genes and factors responsible for this disease occurrence are remained to be discovered (Munye et al., 2017). The gene discussed is MASP1; the disease is 3MC syndrome.