Factors that may also be explored include patients’ previous history of RF or recurrent tonsillitis; family history of RHD; clinical symptoms and signs such as cough, coryza, joint pains, fever, severe inflammation of tonsils, purulent exudate and cardiac murmur; clinical scores (such as FeverPAIN) and point-of-care tests such as C-reactive protein level and rapid diagnostic tests for malaria (in malaria-endemic countries). The gene discussed is CRP; the disease is malaria.