TP53 and chronic myelogenous leukemia, BCR-ABL1 positive: For example, overexpression of La/SSB in CML increases the expression of the proto‐oncogene mouse double minute 2 (MDM2), a member of the tyrosine kinase family, by direct binding of the 5′ UTR of MDM2, thereby enhancing its translation and, in turn, reducing expression of the tumour suppressor protein p53.17