For example, overexpression of La/SSB in CML increases the expression of the proto‐oncogene mouse double minute 2 (MDM2), a member of the tyrosine kinase family, by direct binding of the 5′ UTR of MDM2, thereby enhancing its translation and, in turn, reducing expression of the tumour suppressor protein p53.17 This evidence concerns the gene MDM2 and chronic myelogenous leukemia, BCR-ABL1 positive.