In 67 BCP‐ALL cell lines with the wild‐type NUDT15 genotype, the IC50 (day 7) value in six cell lines with NT5C2 and PRPS1 mutations was significantly higher than 61 cell lines without mutations (0.32 μM, p = 0.0011) (Figure 4E). This evidence concerns the gene NUDT15 and acute lymphoblastic leukemia.