TNF and Cachexia: In line with these findings, in a cachexia mouse model of colon‐26 adenocarcinoma, Liu et al. reported decreased mRNA expression levels and enzymatic activity of CPT I and CPT II and significantly reduced amounts of free carnitine and acetyl‐carnitine compared to normal controls42 and oral administration of high doses of L‐carnitine in this murine model42 or a rat model of cachexia43 improved the condition by reducing serum levels of IL‐6 and TNF‐α and restoring CPT expression and activity to enhanced beta‐oxidation and to decrease adipose tissue breakdown.42