Interestingly, back in 1998, Seelaender et al.40using a model of Walker 256 carcinosarcoma bearing rats affected by severe cachexia found a marked reduction (i.e. −56%) of activity of the isolated mitochondrial inner‐membrane CPT II in comparison with non‐tumour‐bearing, non‐cachectic control animals and identified a lower weight, catalytically less active isoform of CPT II, possibly induced by tumour‐derived factors (i.e. TNF‐α). Here, TNF is linked to Cachexia.