However, despite the potentially unfavourable histological features, IBC-NST with medullary pattern has a relatively good prognosis (2,6,7); notably, this has been associated with the qualitative features of the tumor microenvironment (TILs) and pronounced tumor cell adhesion (involving E-cadherin expression) and absence of matrix metalloproteinase-1 (MMP1) (2,5,6). The gene discussed is MMP1; the disease is neoplasm.