CD274 and cancer: We found that the cancer cells had pronounced proliferative activity (Kі-67 expression), and blocked both natural and drug-induced apoptosis (p53 and Bcl-2 expression), as well as the expression of unfavourable proteins (EGFR, Hsp70, Hsp90, and PD-L1) that induce progression of the neoplastic process (8,9,11–13).